Description
Pharmacological action
Dirofen suspension 20 refers to combined anthelmintic drugs. It has a wide spectrum of anthelmintic action on the mature and larval stages of the development of round and ribbon helminths, which are parasitic in dogs, cats and ferrets (Toxosara sannis, Toxosara mystax, Toxascaris leonina, Taenia solium, Uncinaria ulocisocinocisulocisocinocisulocisulocisocinocisulisomisocisulocisomisocisulocisulocisomisocisulomisocisocenocis, trichurisulococulocisomisulocisocenocis, trichurisuloculococomisulisocis vulcis, , Mesocestoides lineatus, Dipylidium caninum, Diphyllobothrium latum, Multiceps multiceps) and in decorative rodents (Syphacia obvelata, Syphacia muris, Aspiculuris tetraptera, Rodentolepis straminea, Hymenolepis nana, Hymenolepis diminuta). The mechanism of action of praziquantel and pyrantel pamoate, which are part of the drug, is based on the inhibition of fumarate reductase, persistent depolarization of the helminth muscle cells, impaired energy metabolism, which causes paralysis and death of helminths and contributes to their elimination from the gastrointestinal tract. With the oral administration of the drug, praziquantel is rapidly absorbed in the gastrointestinal tract, reaching a maximum concentration in the blood plasma after 1-3 hours, and distributed in the organs and tissues of the animal is excreted from the body mainly with urine (up to 80%) within 24 hours. Pyrantel pamoate is poorly absorbed, which ensures its prolonged effect on helminths in the intestine is excreted from the body mainly unchanged with feces (93%). Dirofen suspension 20, according to the degree of exposure to the body, belongs to low-hazard substances (hazard class 4 according to GOST 12.1.007-76), at the recommended doses they do not have embryotoxic, teratogenic and sensitizing effects. Well tolerated by dogs and cats of different breeds and ages, ferrets and decorative rodents.
Indications
Dirofen suspension 20 is prescribed for adult cats, kittens and puppies from 3 weeks of age, ferrets and decorative rodents from 3-4 weeks of age with a prophylactic and therapeutic purpose for nematodoses (toxocariasis, toxascaridosis, uncinariosis, trichocephalosis, hookworm), cestodoses (teniidosis, dipyldiosis, echinococcosis, diphyllobothriasis, mesocestoidosis) and mixed cestodose-nematodous invasions.
Contraindications
Contraindication to use is individual intolerance to the components of the drug (including a history of). Dirofen suspension should not be used in malnourished patients with infectious diseases and recovering animals, nor should females in the first half of pregnancy, puppies, kittens, rodents and ferrets under 3 weeks of age. If necessary, pregnant women are prescribed the drug 3 weeks before the expected birth with caution, under the supervision of a veterinarian, and nursing females 2-3 weeks after the birth.
Special instructions
Dirofen suspension should not be used simultaneously with piperazine and cholinesterase inhibiting agents. The drug is not intended for use by productive animals.
Composition
The drug Dirofen suspension 20 (for adult cats, kittens, puppies, ferrets and decorative rodents) contains in 1 ml as active ingredients: pyrantel pamoate – 15 mg and praziquantel – 5 mg, as well as excipients: pumpkin oil, tween-80, asasvit C 200, sodium benzoate, Na-carboxymethyl cellulose and purified water.
Side effects of
When using Dirofen suspension in accordance with this instruction, side effects and complications in animals, as a rule, are not observed. With increased individual sensitivity to the components of the drug and the appearance of allergic reactions, its use is stopped and antihistamines and symptomatic therapy are prescribed to the animal.
dosage form
oral suspension
