Description
Pharmacological action
Fungin Forte belongs to the combined antimicrobial drugs. Terbinafine is an antifungal agent of the allylamine group, active against pathogens of dermatomycosis in animals. The mechanism of action is the suppression of squalene epoxidase in the cell membrane of the fungus. This leads to a deficiency of ergosterol and intracellular accumulation of squalene, which causes the death of the pathogen cell. Depending on the concentration, terbinafine exhibits a fungicidal or fungistatic effect. Due to the high lipophilicity, terbinafine molecules accumulate in the stratum corneum of the dermis, hair follicles, sebaceous glands with local application to the systemic circulation to a small extent. Thiabendazole is a fungicide from the class of azoles. Active against pathogens of trichophytosis and microsporia of animal genera Trichophyton, Microsporum, Epidermophyton, Achorion. Like other azoles, it blocks the activity of enzymes involved in the 14-demethylation of lanosterol, which leads to disruption of ergosterol synthesis. A change in the structure of the cytoplasmic membrane of fungal cells leads to a violation of its permeability, exit from the cell biologically active substances and the destruction of the cell wall. In addition, thiabendazole disrupts the process of nuclear division, inhibits the reproductive ability of fungi. Metronidazole is a drug from the group of nitroimidazoles. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of the bacterial cell, inhibiting the synthesis of nucleic acids in it, which leads to the death of the microorganism. Dexamethasone is a synthetic glucocorticosteroid, methylated derivative of fluoroprednisolone. It has anti-inflammatory, anti-allergic, desensitizing, immunosuppressive, anti-shock and antitoxic effects, increases the sensitivity of beta-adrenergic receptors to endogenous catecholamines. The mechanism of action of dexamethasone is to suppress the activity of various tissue-destroying enzymes – proteases and nucleases, matrix metalloproteinases, hyaluronidases, phospholipases, inhibition of the synthesis of prostaglandins, kinins, leukotrienes and other mediators of inflammation from arachidonic acid. Lidocaine – has a local anesthetic effect, blocks potential-dependent sodium channels, which prevents the generation of impulses in the ends of sensory nerves and the conduction of impulses along nerve fibers. Fungin Forte by its degree of exposure to the body belongs to low-hazardous substances (hazard class 4 according to GOST 12.1.007-76), in recommended doses it does not have a local irritant, resorptive-toxic and sensitizing effect. Eye contact causes slight irritation.
Indications
Fungin Forte is prescribed for dogs and cats to treat fungal skin diseases, eczema of fungal etiology and seborrheic dermatitis.
Contraindications
Contraindication to use is the hypersensitivity of the animal to the components of the drug. Weakened animals, lactating and pregnant females are not to be processed, as well as puppies and kittens younger than 4 weeks of age.
Composition
In 1 ml: terbinafine hydrochloride – 10 mg, thiabendazole – 10 mg, metronidazole – 10 mg, lidocaine hydrochloride – 50 mg, dexamethasone sodium phosphate – 1 mg, excipients up to 1 ml.
Dosage and administration of
Fungin Forte is applied in a thin layer using a cotton-gauze swab, as well as spraying or applying directly to the skin from a dropper bottle, gently rubbing into the affected areas from the periphery to the center with the capture of up to 1 cm of borderline healthy skin. Treatments are carried out once or twice a day until clinical recovery, but not more than 15 days, which is confirmed by microscopic examination of skin scrapings. To prevent licking of the drug, animals put on a muzzle, collar or close their jaws with a loop from the braid, which is removed 15 to 20 minutes after treatment. In severe cases of the disease, animals are additionally prescribed medications of specific and symptomatic therapy in accordance with the instructions for use.
active substance
Terbinafine, thiabendazole, metronidazole, lignocaine, dexamethasone
Dosage form
topical solution
